Which Oral Contraceptive Pill is
Best for Me?
Frederick R. Jelovsek MD, MS
"I am 25 years old. I haven't had a period in about
6 months but I don't want to get pregnant now. I'm
overweight and can't lose any, I am always tired,
have acne that I can't clear up, and I have excess
body hair. I have been put on birth control pills
but they haven't helped. What would be the best brand
of pills for me to be on for my problem? Also, my
pills cost $30.00 a month. Are there any sources for
free pills?"
Anonymous
Be sure to give the pills you are currently taking
a fair trial of at least 2-3 months. If your pills
are switched, also give them 2-3 months trial because
it often takes 2 months just for your body to adjust
to the estrogen and progestin in an oral contraceptive.
Also when we say a pill has certain characteristics
because of its estrogen dose and its progestin dose
and potency or androgenicity (male hormone effect),
every woman responds differently to those components
and sometimes the general principles just do not apply.
With your history of infrequent menstruation, you
may have a condition of either polycystic ovarian
syndrome (PCOS) or a stress-like hypothalamic anovulation.
In either case, birth control pills are a good treatment
for those conditions if you do not want to get pregnant
at present. In the case of hypothalamic anovulation
there are often low or low normal estrogen levels
and the pill will increase those levels to mid-normal
range. In the case of PCOS, the extra estrogens from
the pill will result in an increased binding (inactivation)
of any excess testosterone from the polycystic ovaries
as well as suppress some of the testosterone production
from them. With PCOS you would avoid a pill with increased
androgenic (testosterone-like) activity and do better
with one with higher estrogen levels as far as combatting
the excess body hair you indicate is present now.
Many experts believe there are no consistent side
effect differences between different formulations
of birth control pills because all pills have been
reduced in dose so much from when older data on higher
dose pills was examined. Others agree that those unique
side effects have been reduced but they are still
manifest in some women. In my experience some women
still have side effects according to the different
oral contraceptive components and their doses in a
given pill formulation.
How do the doses of pill components vary by brand
of pill? Birth control pills now have only one
(synthetic) estrogen type, ethinyl estradiol. Therefore
the estrogen potency of a given pill is directly related
to the number of micrograms of ethinyl estradiol with
one exception. Sometimes the specific progestin also
has some estrogen activity. For the most part, the
estrogen potency of the progestins is small in comparison
with ethinyl estradiol so it is not added in to potency
tables.
Estrogen and Progestin Hormone Doses in Combined
Birth Control Pills
Estrogen level
ethinyl estradiol
(micrograms) |
Pill Brand Name |
Progestin |
Dose (mg) |
| 20 mcgm |
Alesse® |
levonorgestrel |
0.10 |
| Levlite® |
levonorgestrel |
0.10 |
| Loestrin 1/20® Fe |
norethindrone acetate |
1.00 |
| Mircette® |
desogestrel |
0.15 |
Ortho Evra®
(patch) |
norelgestromin
(norgestimate metabolite) |
0.15 |
phasic
20/30/35 mcgm |
Estrostep® Fe |
norethindrone acetate |
1.0/1.0/1.0 |
| 30 mcgm |
Levlen® |
levonorgestrel |
0.15 |
| Levora® |
levonorgestrel |
0.15 |
| Nordette® |
levonorgestrel |
0.15 |
| Lo/Ovral® |
norgestrel |
0.30 |
| Desogen® |
desogestrel |
0.15 |
| Ortho-Cept® |
desogestrel |
0.15 |
| Loestrin® 1.5/30 |
norethindrone acetate |
1.50 |
| Yasmin® |
drospirenone |
3.0 |
phasic
30/40/30 mcgm |
Triphasil® |
levonorgestrel |
0.05/0.075/0.125 |
| Tri-Levlen® |
levonorgestrel |
0.05/0.075/0.125 |
| Trivora® |
levonorgestrel |
0.05/0.075/0.125 |
| 35 mcgm |
Ortho-Cyclen® |
norgestimate |
0.25 |
| Ovcon-35® |
norethindrone |
0.40 |
| Brevicon® |
norethindrone |
0.50 |
| Modicon® |
norethindrone |
0.50 |
| Necon® |
norethindrone |
1.00 |
| Norethin® |
norethindrone |
1.00 |
| Norinyl® 1/35 |
norethindrone |
1.00 |
| Ortho-Novum® 1/35 |
norethindrone |
1.00 |
| Demulen® 1/35 |
ethynodiol diacetate |
1.00 |
| Zovia® 1/35E |
ethynodiol diacetate |
1.00 |
phasic
35/35 mcgm |
Ortho-Novum® 10/11 |
norethindrone |
0.50/1.00 |
| Jenest® |
norethindrone |
0.50/1.00 |
phasic
35/35/35 mcgm |
Ortho-Tri-Cyclen® |
norgestimate |
0.15/0.215/0.25 |
| Ortho-Novum® 7/7/7 |
norethindrone |
0.50/0.75/1.00 |
| Tri-Norinyl® |
norethindrone |
0.50/1.00/0.50 |
| 50 mcgm |
Necon® 1/50 |
norethindrone |
1.00 |
| Norinyl® 1/50 |
norethindrone |
1.00 |
| Ortho-Novum® 1/50 |
norethindrone |
1.00 |
| Ovcon-50® |
norethindrone |
1.00 |
| Ovral® |
norgestrel |
0.50 |
| Demulen® 1/50 |
ethynodiol diacetate |
1.00 |
| Zovia® 1/50E |
ethynodiol diacetate |
1.00 |
Which pills have higher progestin side effects
or cause more acne and hair growth? Each progestin
has a different potency, milligram per milligram,
in terms of progesterone effect to stop menstrual
bleeding or androgen effect to stimulate acne and
hair growth. However you must remember that a higher
potency progestin may be used in a much smaller milligram
dose and thus be equivalent to a larger milligram
dose of a less potent progestin. For example, desogestrel
is a very potent and androgenic progestin but its
usual oral contraceptive dose is 0.15 mg instead of
1.00 mg for norethindrone. Its progestin potency compared
to norethindrone would be 0.15 X 9.0 = 1.35 times.
For androgenicity, it would be 0.15 X 3.4 = .51 or
half as androgenic as a pill containing 1 mg of norethindrone.
Progestin Potency of Different Oral Contraceptive
Progestins*
| Progestin |
Progestational Activity
(relative to 1 mg of norethindrone) |
Androgenic Activity
(relative to 1 mg of norethindrone) |
| norethindrone 1 mg |
1.0 |
1.0 |
norethrindrone acetate 1 mg |
1.2 |
1.6 |
ethynodiol diacetate 1 mg |
1.4 |
0.6 |
levonorgestrel 1 mg |
5.3 |
8.3 |
dl-norgestrel 1 mg |
2.6 |
4.2 |
norgestimate 1 mg |
1.3 |
1.9 |
norelgestromin 1 mg** |
1.3 |
1.9 |
desogestrel 1 mg |
9.0 |
3.4 |
drospirenone 1 mg |
1.5 |
0.0 |
* - From Table 2 in Dickey RP: Individualizing oral
contraceptive therapy. OBG Management Supplement October
2000, p 5.
** - Not yet tested but it is the major active metabolite
of norgestimate
The pills that are likely to cause worse acne and
hair growth side effects are those pills high in androgenicity
and low in estrogen content. Such pills might include:
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